Plavix and PPIs are bad combination
If you ask people who take PPIs about its safety the answer you most probably will hear: it is totally safe.
Well it looks like it is safe unless you combine it with Plavix. Recent research study found that in patients who suffered heart attack and were prescribed PPIs (in case of study it was Prilosec) together with blood thinner Plavix risk of repeat heart attack doubled in comparison with patients who were prescribed just Plavix. So Plavix+Prilosec equal to double risk of getting repeat heart attack.
It would be nice to get some study to figure out if Plavix+Prilosec are doubling chances of first heart attack. If it is then it should be taken very seriously and every patient prescribed with PPIs should know what risk they may be taking.
Anyway looks like there are some hidden sides in PPIs. It doesn’t mean that we should stop taking them when heartburn is really bad but be careful and if you can find alternatives it maybe time to consider them.
Here you can find more details on this study http://www.healthfinder.gov/News/newsstory.aspx?docid=624675.